Article

Placental pathology, circadian biology, and pathogenesis of spontaneous preterm birth: a pilot study of human placental gene expression profiling using a targeted HTG transcriptome panel

2026-06-29

Abstract excerpt

<h4>BACKGROUND</h4> Spontaneous preterm birth (sPTB) remains the foremost cause of neonatal morbidity and mortality worldwide. Although histologic chorioamnionitis (HCA) and placental vascular abnormalities are frequently observed in sPTB, the molecular cascades linking these lesions to labor initiation remain poorly understood. Emerging evidence implicates circadian dysregulation and trophoblast dysfunction as a...

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Literature Corpus work: 6134a51c-c826-5aaf-8769-47dcee130f9d
DOI: 10.64898/2026.06.23.734020

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