Article

ANTENNA, a Multi-Rank, Multi-Layered Recommender System for Inferring Reliable Drug-Gene-Disease Associations: Repurposing Diazoxide as a Targeted Anti-Cancer Therapy

2017-09-22

Abstract excerpt

<h4>ABSTRACT</h4> Existing 1 drug discovery process follows a reductionist model of “one-drug-one-gene-one-disease,” which is not adequate to tackle complex diseases that involve multiple malfunctioned genes. The availability of big omics data offers new opportunities to transform the drug discovery process into a new paradigm of systems pharmacology that focuses on designing drugs to target molecular interactio...

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Literature Corpus work: 612026b0-f481-5b6c-97aa-31c15cc800bb
DOI: 10.1101/192385

Open publication

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