Article

High-throughput data-driven analysis of myofiber composition reveals muscle-specific disease and age-associated patterns

2018-11-04

Abstract excerpt

Contractile properties of myofibers are dictated by the abundance of myosin heavy chain (MyHC) isoforms. MyHC composition designates muscle function and its alterations could unravel differential muscle involvement in muscular dystrophies and aging. Current analyses are limited to visual assessments in which myofibers expressing multiple MyHC isoforms are prone to misclassifications. As a result, complex patterns...

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Literature Corpus work: 5fffe635-1899-5d54-9293-3b5f88b0a8d5
DOI: 10.1101/461608

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