Article

Rare variants in SLC34A3 explain missing heritability of urinary stone disease

2022-12-05

Abstract excerpt

Urinary stone disease (USD) is a major health burden affecting >10% of the UK population at some time. While stone disease is strongly associated with lifestyle, genetic factors also predispose to USD: common genetic variants at multiple loci from genome-wide association studies account for 5% of the estimated 45% heritability of the disorder. We investigated the extent to which rare genetic variation contributes...

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Literature Corpus work: 5f1db9c9-c0da-5dab-a671-b689bfc2fd34
DOI: 10.1101/2022.12.02.22283024

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