Article

Discovery of small molecule protease inhibitors by investigating a widespread human gut bacterial biosynthetic pathway

2018-03-26

Abstract excerpt

Natural products from the human microbiota may mediate host health and disease. However, discovery of the biosynthetic gene clusters that generate these metabolites has far outpaced identification of the molecules themselves. Here, we used an isolation-independent approach to access the probable products of a nonribosomal peptide synthetase-encoding gene cluster from Ruminococcus bromii, an abundant gut commensal...

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Literature Corpus work: 5efd3f9a-c8ab-59fc-ad4f-f4c25fc3079d
DOI: 10.1016/j.tet.2018.03.043

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