Article

Combining Tissue and Circulating Tumor DNA Increases the Detection Rate of CTNNB1 Mutation in Hepatocellular Carcinoma

2020-10-09

Abstract excerpt

<title>Abstract</title> <p><bold>Background and aims</bold>: Studies suggest that mutations in the <italic>CTNNB1</italic> gene are predictive of response to immunotherapy, an emerging therapy for advanced hepatocellular carcinoma (HCC). Analysis of circulating tumor DNA (ctDNA) offers the possibility of serial non-invasive mutational profiling of tumors. Combining tumor tissue and ctDNA analysis may increase the...

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Literature Corpus work: 5e7b135e-646a-5e3d-8d24-54e545aed7be
DOI: 10.21203/rs.3.rs-88929/v1

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