Back to search

Article

Association between the 4p16 genomic locus and different types of congenital heart disease: results from adult survivors in the UK Biobank

2019-09-06

Abstract excerpt

<h4>ABSTRACT</h4> Congenital heart disease is the most common birth defect in newborns and the leading cause of death in infancy, affecting nearly 1% of live births. A locus in chromosome 4p16, adjacent to MSX1 and STX18 , has been associated with atrial septal defects (ASD) in multiple European and Chinese cohorts. Here, genotyping data from the UK Biobank was used to test for associations between this locus a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5d5bccfa-d7ad-5c9e-9408-034ca67d2394
DOI
10.1101/760371
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Association between the 4p16 genomic locus and different types of congenital heart disease: results from adult survivors in the UK BiobankDOI 10.1101/760371
Association between the 4p16 genomic locus and different types of congenital heart disease: results from adult survivors in the UK Biobank.Semantic proximity
Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16.Semantic proximity
Association between the European GWAS-identified susceptibility locus at chromosome 4p16 and the risk of atrial septal defect: a case-control study in Southwest China and a meta-analysis.Semantic proximity
Association Between the 4p16 Susceptibility Locus and the Risk of Atrial Septal Defect in Population from Southeast China.Semantic proximity
Replication of the 4p16 susceptibility locus in congenital heart disease in Han Chinese populations.Semantic proximity
Genome-wide association studies highlight novel risk loci for septal defects and left-sided congenital heart defects.Semantic proximity
Exploring Genetic Diversity of SOD2 and POU5F1 for Congenital Heart Disease in the Southwest Chinese Population.Semantic proximity
A rare mutation (p.Ala264Thr) of GATA4 is responsible for atrial septal defect and pulmonary valve stenosis.Semantic proximity
Human Genetics of Atrial Septal Defect.Semantic proximity
<i>STX18-AS1</i> is a Long Noncoding RNA predisposing to Atrial Septal Defect via downregulation of <i>NKX2-5</i> in differentiating cardiomyocytesSemantic proximity
The M310T mutation in the GATA4 gene is a novel pathogenic target of the familial atrial septal defect.Semantic proximity
Phenotype of ASDs Associated With 4p16 Risk Locus and Novel Genome-Wide Associations of ASD Patients in the Finnish Population.Semantic proximity
Select a neighboring publication to make it the new centre.