Article
Association between the European GWAS-identified susceptibility locus at chromosome 4p16 and the risk of atrial septal defect: a case-control study in Southwest China and a meta-analysis.
PloS one - 1 Jan 2015
Zhao Li, Li Bei, Dian Ke, Ying Binwu, Lu Xiaojun, Hu Xuejiao, An Qi, Chen Chunxia, Huang Chunyan, Tan Bin, Qin Li
Abstract excerpt
Atrial septal defect (ASD) is the third most frequent type of congenital heart anomaly, featuring shunting of blood between the two atria. Gene-environment interaction remains to be an acknowledged cause for ASD occurrence. A recent European genome-wide association study (GWAS) of congenital heart disease (CHD) identified 3 susceptibility SNPs at chromosome 4p16 associated with ASD: rs870142, rs16835979 and...
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