Article

Symptom Distribution Heterogeneity as a Marker for the Course of Major Depression

2025-07-14

Abstract excerpt

<title>Abstract</title> <p>Major Depressive Disorder (MDD) presents diverse symptom patterns, such as sadness or fatigue, influencing its course and treatment response. Using dynamical systems and network theories, which model depression as interconnected symptoms stabilizing in specific patterns (attractor dynamics), we examined whether symptom structure reflects clinical state stability. We applied four mathema...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5c807e02-e4ac-5144-a0f8-7665113c3cff
DOI: 10.21203/rs.3.rs-7047188/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Symptom Distribution Heterogeneity as a Marker for the Course of Major DepressionDOI 10.21203/rs.3.rs-7047188/v1Read

Depressive Symptoms as a Heterogeneous and Constantly Evolving Dynamical System: Idiographic Depressive Symptom Networks of Rapid Symptom Changes among Persons with Major Depressive DisorderSemantic proximity Read

First vs recurrent episode symptomatology in Major Depressive Disorder and its relation to brain function and structure: a network approachSemantic proximity Read

Temporal dynamics of depressive symptomatology: An idiographic time series analysis applying network models to patients with depressive disordersSemantic proximity Read

Unique genetic and risk-factor profiles in multimorbidity clusters of depression-related disease trajectories from a study of 1.2 million subjectsSemantic proximity Read

Clinical stratification of Major Depressive Disorder in the UK Biobank: A gene-environment-brain Topological Data AnalysisSemantic proximity Read

Dissection of the clinical phenome of major depressive disorder into subdomains and subgroups in relation to activated immune-inflammatory profilesSemantic proximity Read

Prediction of antidepressant treatment response with thalamo-somatomotor functional connectivity revealed by generalizable stratification of depressed patientsSemantic proximity Read

Inflammatory phenotype of depression symptom structure: A network perspective.Semantic proximity Read

Functional and Optogenetic Approaches to Discovering Stable Subtype-Specific Circuit Mechanisms in DepressionSemantic proximity Read

Symptom networks in major depression do not diverge across sex, familial risk, and environmental risk.Semantic proximity Read

Predicting individual clinical trajectories of depression with generative embeddingSemantic proximity Read

Contrastive functional connectivity defines neurophysiology-informed symptom dimensions in major depressionSemantic proximity Read