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The genome analysis of <i>Tripterygium wilfordii</i> reveals TwCYP712K1 and <i>TwCYP712K2</i> responsible for oxidation of friedelin in celastrol biosynthesis pathway

2020-06-30

Abstract excerpt

<h4>ABSTRACT</h4> Tripterygium wilfordii is a Traditional Chinese Medicine (TCM) from family Celastraceae and celastrol is one of the strongest active ingredients belonging to friedelane-type pentacyclic triterpenoid, which has a large clinical application value of anti-tumor, immunosuppression, and obesity treatment. The first committed biosynthesis step of celastrol is the cyclization of 2, 3-oxidosqualene to f...

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Literature Corpus work
5b09ed1e-58dd-574f-8d16-11ac1d46265b
DOI
10.1101/2020.06.29.176958
Open publication

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The genome analysis of <i>Tripterygium wilfordii</i> reveals TwCYP712K1 and <i>TwCYP712K2</i> responsible for oxidation of friedelin in celastrol biosynthesis pathwayDOI 10.1101/2020.06.29.176958
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