Article

JAG1 Variants Confer Genetic Susceptibility to Thyroid Dysgenesis and Thyroid Dyshormonogenesis with Different Mechanisms

2022-12-02

Abstract excerpt

<title>Abstract</title> <p>Background and objective: Congenital hypothyroidism (CH) is the most common and preventable neonatal endocrine disorder, with an incidence of 1 in 2000–3000 newborns worldwide, and 1 in 2400 in China. However, the genetic causes of congenital hypothyroidism, in particular due to thyroid dysgenesis (TD) remain largely unknown. Previous study indicated that <italic>JAG1</italic> is a nov...

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Literature Corpus work: 5a8146df-5d1a-53d2-b0e7-cc7ad836365f
DOI: 10.21203/rs.3.rs-2316641/v1

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