Limited generalizability of dynamic fMRI correlates of adolescent rumination

Abstract excerpt

Rumination, or perseverative negative self-referential thinking, is a hallmark of depression. In adults, a dynamic resting-state fMRI model of trait rumination was recently identified through predictive modelling. In adolescents, a development period during which rumination and depression increase, the neurobiological correlates of ruminative thinking are less clear. In the current preregistered study, we examine...

Topics

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• Adaptation, Psychological
• Brain-Derived Neurotrophic Factor
• Child of Impaired Parents
• Depressive Disorder
• Mothers
• Risk Factors
• Serotonin Plasma Membrane Transport Proteins
• Surveys and Questionnaires

Identifiers and source

Literature Corpus work

59e40955-cfcc-595c-9fae-9961f21a2ecd

DOI

10.1101/2025.08.29.673124