Unveiling Lipid Metabolism-related Gene PTGDS: A Tumor Suppressor in Lung Adenocarcinoma with Therapeutic Potential

Abstract excerpt

<title>Abstract</title> <p>Background Lung adenocarcinoma (LUAD) remains a leading cause of cancer-related mortality worldwide. Although the lipid metabolism-associated gene PTGDS has been implicated in tumorigenesis, its functional significance and regulatory mechanisms in LUAD are poorly understood. Methods We integrated multi-omics data from TCGA and GEO cohorts to evaluate PTGDS expression and its clinicopath...

Topics

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• Biomarkers, Tumor
• Carcinoma, Non-Small-Cell Lung
• Carcinoma, Squamous Cell
• Cytochrome P-450 Enzyme System
• Gene Expression Regulation, Neoplastic
• Lipid Metabolism
• Lung
• Phospholipases A

Identifiers and source

Literature Corpus work

58dc35ca-f05f-5714-84d0-89b7dfccfcfc

DOI

10.21203/rs.3.rs-7946797/v1