Article

Smoking and SARS-CoV-2 Impair Dendritic Cells and Regulate DC-SIGN Expression in Tissues

2020-12-30

Abstract excerpt

<h4>Summary</h4> The current spreading novel coronavirus SARS-CoV-2 is highly infectious and pathogenic. In this study, we screened the gene expression of three SARS-CoV-2 host receptors (ACE2, DC-SIGN and L-SIGN) and DC status in bulk and single cell transcriptomic datasets of upper airway, lung or blood of smokers, non-smokers and COVID-19 patients. We found smoking increased DC-SIGN gene expression and inhibite...

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Identifiers and source

Literature Corpus work: 58d9c048-7996-5406-8822-25dd4ea37fe1
DOI: 10.1101/2020.12.23.20245316

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