Analysis of expression pattern and prognostic value of the HPSE in breast cancer through CD274/CTLA-4 immune checkpoint proteins

Abstract excerpt

Heparanase (HPSE), an endoglycosidase that cleaves heparan sulfate, regulates various biological processes related to tumor progression. In the study, we further explored the prognostic value of HPSE through the TCGA database. Our model demonstrated that the integrating of HPSE with the clinical stage effectively predicts patients' survival time, highlighting high HPSE expression as a prognostic risk factor for br...

Topics

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• Biomarkers, Tumor
• Breast Neoplasms
• Gene Expression Profiling
• Gene Expression Regulation, Neoplastic
• Immunophenotyping
• Lymphocytes, Tumor-Infiltrating
• Mutation
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

57a93c06-e6cc-5ae5-aa25-831eba477305

DOI

10.21203/rs.3.rs-3978321/v1