Back to search

Article

Characterising the microbial and antimicrobial resistance signatures of hospital-acquired pneumonia using nanopore metagenomic sequencing

2025-08-18

Abstract excerpt

<title>Abstract</title> <p>Hospital-acquired pneumonia (HAP) is a significant burden in nosocomial settings, yet its microbial underpinnings remain poorly understood. Here, we leverage shotgun nanopore sequencing to characterise the respiratory microbiomes of 250 HAP patients in a UK multi-site cohort, validating these using paired PCR and culture assays. Sequencing identified the dominant microbes implicated in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
57168c0f-79e2-56e6-8176-bbd3f19d5cb5
DOI
10.21203/rs.3.rs-7332980/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Characterising the microbial and antimicrobial resistance signatures of hospital-acquired pneumonia using nanopore metagenomic sequencingDOI 10.21203/rs.3.rs-7332980/v1
Characterising the microbial and antimicrobial resistance signatures of hospital-acquired pneumonia using nanopore metagenomic sequencingSemantic proximity
Metagenomic identification of severe pneumonia pathogens with rapid Nanopore sequencing in mechanically-ventilated patientsSemantic proximity
Metagenomic identification of severe pneumonia pathogens in mechanically-ventilated patients: a feasibility and clinical validity studySemantic proximity
Clinical Efficacy and Diagnostic Value of Metagenomic Next-Generation Sequencing (mNGS) in Hospital-Acquired Pneumonia: A Stratified Retrospective Study of Responders and Non- RespondersSemantic proximity
Metagenomic Diagnosis for a Culture-Negative Sample From a Patient With Severe Pneumonia by Nanopore and Next-Generation SequencingSemantic proximity
Potential utility of targeted Nanopore sequencing for improving etiologic diagnosis of bacterial and fungal respiratory infectionSemantic proximity
Application of respiratory metagenomics for COVID-19 patients on the intensive care unit to inform appropriate initial antimicrobial treatment and rapid detection of nosocomial transmissionSemantic proximity
Clinical Metagenomics for the Management of Hospital- and Healthcare-Acquired PneumoniaSemantic proximity
The application of targeted nanopore sequencing for the identification of pathogens and resistance genes in lower respiratory tract infectionsSemantic proximity
Nanopore metagenomics enables rapid clinical diagnosis of bacterial lower respiratory infectionSemantic proximity
Cartography of opportunistic pathogens and antibiotic resistance genes in a tertiary hospital environmentSemantic proximity
Analysis of hospital air microbiomes uncovers potential avenues for transmission of diverse pathogens linked to hospital-acquired infectionsSemantic proximity
Select a neighboring publication to make it the new centre.