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Nonmyeloablative Pentostatin-Cyclophosphamide Preconditioning Improves Rates of Engraftment in Adults Undergoing Haploidentical HCT for Sickle Cell Disease

2025-09-02

Abstract excerpt

The morbidity and mortality of sickle cell disease (SCD) remain high. Novel nonmyeloablative haploidentical hematopoietic cell transplant (HCT) regimens are being proposed. <h4>Methods</h4> This report compared the effect of adding an oral cyclophosphamide and IV pentostatin (PC) preconditioning to the nonmyeloablative NIH HCT platform of alemtuzumab and total body irradiation (TBI). <h4>Results</h4> Thirty-nine...

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Literature Corpus work
567f4a39-9e39-5c97-802e-7d1824c18d5b
DOI
10.1101/2025.08.31.25334807
Open publication

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Nonmyeloablative Pentostatin-Cyclophosphamide Preconditioning Improves Rates of Engraftment in Adults Undergoing Haploidentical HCT for Sickle Cell DiseaseDOI 10.1101/2025.08.31.25334807
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