Article

A Precision Screening Framework for Thalassemia in a High-Mobility Population: Integrating 3D Phenotypic Mapping and Genotype-Specific Thresholds

2026-04-06

Abstract excerpt

<title>Abstract</title> <p> Objective In regions characterized by high hemoglobinopathy prevalence and significant population mobility, defining population-specific diagnostic thresholds is critical to overcoming "phenotypic masking" in complex thalassemia genotypes. This study evaluates the diagnostic utility of hematological indices and <italic>HbA</italic> <sub> <italic>2</italic> </sub> through a novel...

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Literature Corpus work: 5514b317-573a-5582-856d-e2cfd4e537f9
DOI: 10.21203/rs.3.rs-9213369/v1

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