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SGLT2-Inhibition reverts urinary peptide changes associated with severe COVID-19: an<i>in-silico</i>proof-of-principle of proteomics-based drug repurposing

2021-07-22

Abstract excerpt

Severe COVID-19 is reflected by significant changes in multiple urine peptides. Based on this observation, a clinical test based on urinary peptides predicting COVID-19 severity, CoV50, was developed and registered as IVD in Germany. We have hypothesized that molecular changes displayed by CoV50, to a large degree likely reflective of endothelial damage, can be significantly reversed by specific drugs. To test thi...

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Literature Corpus work
52ad33fe-37cb-5af0-8a6d-560212332fe9
DOI
10.1101/2021.07.21.21260351
Open publication

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SGLT2-Inhibition reverts urinary peptide changes associated with severe COVID-19: an<i>in-silico</i>proof-of-principle of proteomics-based drug repurposingDOI 10.1101/2021.07.21.21260351
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