Article

The LMSz method - an automatable scalable approach to constructing gene-specific growth charts in rare disorders

2024-08-20

Abstract excerpt

<h4>Introduction</h4> Children with monogenic neurodevelopmental disorders often grow abnormally. Gene-specific growth charts would be useful but require large samples to construct them using the conventional LMS method. <h4>Methods</h4> We transformed anthropometry to British 1990 reference z-scores for 328 UK and 264 international probands with ANKRD11, ARID1B, ASXL3, DDX3X, KMT2A or SATB2- related disorders, an...

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Literature Corpus work: 519228a6-3853-54c1-83b5-ab21e58ca70a
DOI: 10.1101/2024.08.19.24312213

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