Back to search

Article

Oral Pretreatment with Galantamine Effectively Mitigates the Acute Toxicity of a Supra-Lethal Dose of Soman in Cynomolgus Monkeys Post-treated with Conventional Antidotes

2020-02-04

Abstract excerpt

The present study was designed to evaluate the effectiveness of galantamine administered orally as a pre-treatment to mitigate the acute toxicity of 4.0xLD50 soman in Cynomolgus monkeys post-treated with atropine, 2-PAM, and midazolam. Pharmacokinetic experiments revealed that the oral doses of 1.5 and 3.0 mg/kg galantamine HBr were quickly absorbed and produced plasma concentrations of galantamine that generated...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
515d0e9a-0d90-5db9-8426-382dabef5e5d
DOI
10.1101/2020.02.03.932798
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Oral Pretreatment with Galantamine Effectively Mitigates the Acute Toxicity of a Supra-Lethal Dose of Soman in Cynomolgus Monkeys Post-treated with Conventional AntidotesDOI 10.1101/2020.02.03.932798
Galantamine pharmacokinetics, safety, and tolerability profiles are similar in healthy Caucasian and Japanese subjects.Semantic proximity
Nasal Application of the Galantamine Pro-drug Memogain Slows Down Plaque Deposition and Ameliorates Behavior in 5X Familial Alzheimer's Disease Mice.Semantic proximity
Toxicity of amphetamines: an update.Semantic proximity
Dyskinesia after Levetiracetam Therapy: A Case ReportSemantic proximity
Ambroxol for the Treatment of Patients With Parkinson Disease With and Without Glucocerebrosidase Gene Mutations: A Nonrandomized, Noncontrolled Trial.Semantic proximity
Guidelines for Seizure Prophylaxis in Patients Hospitalized withNon-Traumatic Intracerebral Hemorrhage:A Clinical Practice Guideline for Healthcare Professionals from the Neurocritical Care SocietySemantic proximity
Antimicrobial Agent Triclosan Inhibits Acetylcholinesterase Activity <i>in Vitro</i> in a Dose-Dependent MannerSemantic proximity
Safety and tolerability of intravenous liposomal GM1 in patients with Parkinson disease: A single center open-label clinical phase I trial (NEON trial)Semantic proximity
Select a neighboring publication to make it the new centre.