A Phase-2 RCT of a Voice-based AI Coach for Depression and Anxiety

Abstract excerpt

<h4>Background</h4> Clinical evidence regarding artificial intelligence (AI) mental health interventions remains limited. This phase 2 trial investigated the mechanisms and efficacy of a rule-based AI coach, Lumen, delivering problem-solving therapy (PST) via voice for adults with clinically significant symptoms of depression and/or anxiety. <h4>Methods</h4> Participants were randomized to Lumen (n=100), human-c...

Topics

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• Algorithms
• Artificial Intelligence
• Depression
• Electronic Health Records
• Inpatients
• Major Depressive Disorder
• Phenotype
• Precision Medicine

Identifiers and source

Literature Corpus work

5079ed97-8bee-5f3b-9993-1dcd6a9b4c58

DOI

10.64898/2025.12.22.25342792