Back to search

Article

Pyridostigmine and low-dose naltrexone for ME/CFS: study protocol for the Life Improvement Trial (LIFT), a randomized, double-blind, placebo-controlled clinical trial

2025-03-04

Abstract excerpt

<title>Abstract</title> <p>Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, chronic disease with no FDA-approved treatments. This report describes a protocol for the Life Improvement Trial (LIFT), a randomized, double-blind, placebo-controlled clinical trial investigating the impact of low-dose naltrexone (LDN) and pyridostigmine (Mestinon) on physiological response, symptoms,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
50750ee1-c620-5291-b8c7-05b894d8ff4a
DOI
10.21203/rs.3.rs-5626167/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Pyridostigmine and low-dose naltrexone for ME/CFS: study protocol for the Life Improvement Trial (LIFT), a randomized, double-blind, placebo-controlled clinical trialDOI 10.21203/rs.3.rs-5626167/v1
Multimodal approach to identify neuropsychophysiological subgroups in myalgic encephalomyelitis/chronic fatigue syndrome and their relevance for rehabilitation: protocol for a mechanistic cross-sectional and longitudinal studySemantic proximity
Low dose naltrexone for the treatment of fibromyalgia: Protocol for a double-blind, randomized, placebo-controlled trialSemantic proximity
Patient-Reported Treatment Outcomes in ME/CFS and Long COVIDSemantic proximity
Perioperative outcomes in patients with myalgic encephalomyelitis/chronic fatigue syndrome undergoing general anesthesia: a retrospective matched-pair studySemantic proximity
Forming a Consensus Opinion on Long COVID Support Mechanisms and Interventions Using a Modified Delphi ApproachSemantic proximity
Low Dose Naltrexone Prescribing Practices for Children and Adolescents with Long COVIDSemantic proximity
STIMULATE-ICP: A pragmatic, multi-centre, cluster randomised trial of an integrated care pathway with a nested, Phase III, open label, adaptive platform randomised drug trial in individuals with Long COVID: a structured protocolSemantic proximity
Could the kynurenine pathway be the key missing piece of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) complex puzzle?Semantic proximity
The Study Protocol for GENESIS: GENEral population normS—An International SurveySemantic proximity
Provocation of Brachial Plexus and Systemic Symptoms During the Elevated Arm Stress Test in Individuals With Myalgic Encephalomyelitis/chronic Fatigue Syndrome or Idiopathic Chronic FatigueSemantic proximity
The Locus Coeruleus Norepinephrine Depletion Hypothesis of ME/CFS: A Mechanistic Model with Testable Predictions and Multimodal Study Plans (Protocol Framework)Semantic proximity
Insights From Invasive Cardiopulmonary Exercise Testing of Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.Semantic proximity
Select a neighboring publication to make it the new centre.