Article

The Locus Coeruleus Norepinephrine Depletion Hypothesis of ME/CFS: A Mechanistic Model with Testable Predictions and Multimodal Study Plans (Protocol Framework)

2026-01-21

Abstract excerpt

<h4>Background: </h4> Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is character-ised by dysautonomia, unrefreshing sleep, and post-exertional malaise. Epidemiologicalstudies have identified an association between adverse childhood experiences (ACEs) andME/CFS risk, but the mechanistic links underlying this relationship remain unclear. Hypothesis: We propose that repeated corticotropin-releasing fact...

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Literature Corpus work: c458ddb3-404d-58d1-b177-e719b1ec4c0e
DOI: 10.20944/preprints202512.1660.v3

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