Article

The circular RNA landscape of human dorsal root ganglia and its association with opioid exposure

2025-03-01

Abstract excerpt

Opioids are among the most widely prescribed treatments for pain; however, prolonged use leads to adverse effects, including reduced analgesic efficacy (tolerance) and paradoxically heightened pain sensitivity (opioid-induced hyperalgesia, OIH). Neurons that detect noxious stimuli within the dorsal root ganglion (DRG), referred to as nociceptors, mediate both the beneficial and maladaptive effects of opioids. Alth...

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Literature Corpus work: 4fe91364-ad39-5ae8-85e6-2c3120a51232
DOI: 10.1101/2025.02.26.640459

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