Decoding Heart Failure-Associated Transcriptomic Signatures via RNA Sequencing and Structure Based Docking Studies of Flavone Derivatives Targeting AXL Kinase

Abstract excerpt

<title>Abstract</title> <p>Heart failure (HF) is prevalent cardiovascular diseases that significantly impact the health of patients. Although efforts have been made to clarify its pathology, the underlying molecular mechanisms of HF are still not clear. We aimed to explore the molecular mechanism and identify some new diagnostic or therapeutic targets for HF treatment via bioinformatics analysis. The RNA-sequenci...

Topics

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• Cardiovascular Agents
• Databases, Genetic
• Drug Discovery
• Gene Regulatory Networks
• Heart Failure
• Molecular Docking Simulation
• Myocytes, Cardiac
• Protein Interaction Maps

Identifiers and source

Literature Corpus work

4f8bdf12-3ead-5cfe-82cd-2728df1993a5

DOI

10.21203/rs.3.rs-8753796/v1