Article

5’isomiR-183-5p|+2 Elicits Tumor Suppressor Activity in a Negative Feedback Loop with E2F1

2022-01-24

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>MicroRNAs (miRNAs) and isomiRs play important roles in tumorigenesis as essential regulators of gene expression. 5’isomiRs exhibit a shifted seed sequence compared to the canonical miRNA, resulting in different target spectra and thereby extending the phenotypic impact of the respective common pre-miRNA. However, for most miRNAs, expression and function of 5’iso...

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Literature Corpus work: 4f8b3bf0-7017-5613-bb91-e9f164c3784f
DOI: 10.21203/rs.3.rs-1268053/v1

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