Developing a PANoptosis Signature: Identification of Unique Immunotherapeutic Candidates for Osteosarcoma

Abstract excerpt

<title>Abstract</title> <p>This study focused on elucidating the role of PANoptosis in osteosarcoma (OS), a highly malignant bone tumor. By screening and integrating OS-related microarray datasets from GEO, we identified 105 PANoptosis-related differentially expressed genes (OS_PAN_DEGs) primarily involved in apoptosis, necroptosis, proteasome, Hippo signaling, and neurodegenerative disease pathways. These genes...

Topics

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• Autophagy in Disease and Therapy
• Circular RNAs in diseases
• Endoplasmic Reticulum Stress and Disease
• Ferroptosis and cancer prognosis
• Inflammasome and immune disorders
• Liver Disease Diagnosis and Treatment
• RNA modifications and cancer
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

4e586cf6-c6e3-5d51-9b79-ea908a7139c8

DOI

10.21203/rs.3.rs-4488764/v1