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Emerging 4D-Printed pH-Responsive Nanofiber Implants for Spatiotemporal Breast Cancer Therapy: Design Principles, Tumour Microenvironment Modulation, Translational Barriers, and Future Perspectives

2026-03-04

Abstract excerpt

Breast cancer remains one of the leading causes of cancer-related morbidity and mortality worldwide, with tumour recurrence and therapeutic resistance largely driven by the immunosuppressive tumour microenvironment (TME). Conventional systemic chemotherapy and immunotherapy often suffer from poor tumour selectivity, systemic toxicity, and limited immune activation within the acidic and hypoxic TME. In this context...

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Literature Corpus work: 4e24188e-f841-5043-aa44-3f54a2e3df00
DOI: 10.20944/preprints202603.0251.v1

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