Article

The Role of miRNA-377 as a Tumor Suppressor in Lung Cancer by Negative Regulation of Genes Belonging to ErbB Signaling Pathway

2021-07-30

Abstract excerpt

<title>Abstract</title> <p>The ErbB signaling pathway plays important role in the pathogenesis of lung cancer. We explored the role of miRNA-377 as a tumor suppressor in NSCLC through silencing of some genes in the ErbB pathway.Targeting the effect of miRNA-377 on EGFR, MAPK1, ABL2, and PAK2 was evaluated. The expression levels of these genes and miRNA-377 were surveyed in NSCLC and normal human tissues, Calu-6,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4d647b61-ee26-5124-b56a-1a9bedde3a9a
DOI: 10.21203/rs.3.rs-730456/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Role of miRNA-377 as a Tumor Suppressor in Lung Cancer by Negative Regulation of Genes Belonging to ErbB Signaling PathwayDOI 10.21203/rs.3.rs-730456/v1Read

The role of miRNA-377 as a tumor suppressor in lung cancer by negative regulation of genes belonging to ErbB signaling pathwaySemantic proximity Read

Non-small-cell lung cancer and miRNAs: novel biomarkers and promising tools for treatment.Semantic proximity Read

MicroRNAs as the critical regulators of tyrosine kinase inhibitors resistance in lung tumor cells.Semantic proximity Read

Critical microRNAs in Lung Cancer: Recent Advances and Potential ApplicationsSemantic proximity Read

Regulation of NSCLC Cell Proliferation By MARCH7 Via the NF-κB and Wnt/β-Catenin Signaling PathwaysSemantic proximity Read

Investigation of miR-136-5p key target genes and pathways in lung squamous cell cancer based on TCGA database and bioinformatics analysisSemantic proximity Read

Upregulation of microRNA-483-5p Advances Non-small Cell Lung Cancer (NSCLC) Progression via Stifling HIPK2 ExpressionSemantic proximity Read

MicroRNA-567 inhibits cell proliferation and induces cell apoptosis in A549 NSCLC cells by regulating cyclin-dependent kinase 8Semantic proximity Read

Clinicopathological Significance of Up-Regulated Pir-1366 in NSCLC and its Effect on Tumor Migration and MetastasisSemantic proximity Read

The suppressive role of miR-542-5p in NSCLC: the evidence from clinical data and in vivo validation using a chick chorioallantoic membrane modelSemantic proximity Read

A brief overview of the role of microRNA-338 in carcinogenesisSemantic proximity Read

MicroRNA-148b regulates tumor growth of non-small cell lung cancer through targeting MAPK/JNK pathwaySemantic proximity Read