Article

Enhancement of hidden Markov model analyses for improved inference of archaic introgression in modern humans

2025-04-23

Abstract excerpt

Insights into the admixture history between modern and archaic humans require accurately inferred introgressed fragments within modern genomes. Here, we introduce two enhancements to hidden Markov models (HMMs) implemented in hmmix. First, we develop a method for sampling hidden state sequences conditional on observed genomic data, enabling robust estimation of admixture summary statistics—such as admixture propor...

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Literature Corpus work: 4bd4d9be-9f84-51d0-a3c9-8ab8488cc519
DOI: 10.1101/2025.04.22.649993

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