Article

Brain network hypersensitivity underlies pain crises in sickle cell disease

2023-10-09

Abstract excerpt

Sickle cell disease (SCD) is a genetic disorder causing blood vessel blockages and painful Vaso-occlusive crises (VOCs). VOCs, characterized by severe pain due to blocked blood flow, are recurrent and unpredictable, posing challenges for preventive strategies. In this study we propose explosive synchronization (ES), a phenomenon characterized by abrupt brain network phase transitions, as a novel approach to addres...

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Literature Corpus work: 4ba48fad-4f0a-5db6-9044-fd9d94145e83
DOI: 10.1101/2023.10.08.23296715

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