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Article

Tolerance Induction by Viral In Vivo Gene Transfer

1 Nov 2005

Abstract excerpt

Treatment of genetic disease by protein or gene replacement therapy is hampered by immune responses to the therapeutic protein. An excellent example is formation of inhibitory antibodies to coagulation factors in treatment of the X-linked bleeding disorder hemophilia. Experiments in murine and canine models of hemophilia B (deficiency in factor IX) have demonstrated sustained therapeutic levels of factor IX...

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Identifiers

PMID: 16303889
DOI: 10.3121/cmr.3.4.234

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Tolerance Induction by Viral In Vivo Gene TransferPMID 16303889Read ↗

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Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transferSemantic proximity Read ↗

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Effective gene therapy for haemophilic mice with pathogenic factor IX antibodiesSemantic proximity Read ↗

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