Article

The impact of ancestral, environmental and genetic influences on germline <i>de novo</i> mutation rates and spectra

2024-05-21

Abstract excerpt

D e novo germline mutation is an important factor in the evolution of allelic diversity and disease predisposition in a population. Here, we study the influence of genetically-inferred ancestry and environmental factors on de novo mutation rates and spectra. Using a genetically diverse sample of ∼10K whole-genome sequenced trios, one of the largest de novo mutation catalogues to date, we found that genetically-...

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Literature Corpus work: 4ad1cbe3-b1b9-566a-a718-58e53d1daf1c
DOI: 10.1101/2024.05.17.594464

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