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Targeting PRKACA inhibits proliferation and sensitizes glioma cells to temozolomide via pyroptosis pathway

2023-11-07

Abstract excerpt

<title>Abstract</title> <p>Temozolomide is a major chemotherapeutic agent in the clinical treatment of gliomas. Unfortunately, patients usually develop drug resistance. Pyroptosis is recently considered as a new type of programmed cell death, however, the effect and mechanism of the pyroptosis pathway in glioma are unclarified. Gene expression profiles were obtained from the public databases. A total of 37 differ...

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Literature Corpus work
4ace0ad2-a43b-5e7a-9bc8-40b4b7d055e4
DOI
10.21203/rs.3.rs-3544645/v1
Open publication

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