Stress-associated purinergic receptors code for fatal suicidality in the hippocampal-hypothalamic-prefrontal circuit

Abstract excerpt

Imbalanced purine metabolism is a key neurological basis for suicide and mood disorders (MD), wherein purinergic receptors in stress-sensitive cerebral regions are thought to be differentially activated. A hippocampal network that links the hypothalamus and prefrontal cortex implements an affective sensation of stress. We discovered that the hippocampus encoded fatal suicidal ideations in the dentate gyrus (DG) by...

Topics

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• Behavioral Symptoms
• Functional Neuroimaging
• Hypothalamo-Hypophyseal System
• Neuronal Plasticity
• Neurotransmitter Agents
• Pituitary-Adrenal System
• Risk Assessment
• Suicide, Attempted

Identifiers and source

Literature Corpus work

49a7261d-0fe9-5662-af23-b3c41a108344

DOI

10.1101/2022.11.22.516142