Article

SKSR1 identified as key virulence factor in <i>Cryptosporidium</i> by genetic crossing

2024-01-29

Abstract excerpt

Cryptosporidium parvum is a major cause of severe diarrhea. Although isolates of this zoonotic parasite exhibit significant differences in infectivity and virulence, the genetic determinants for these traits are not clear. In this study, we used classical genetics to cross two C. parvum isolates of different virulence and used bulked segregant analysis of whole-genome sequence data from the progeny to identify qu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 47f8e446-f6c4-582c-b534-91e379165cb7
DOI: 10.1101/2024.01.29.577707

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SKSR1 identified as key virulence factor in <i>Cryptosporidium</i> by genetic crossingDOI 10.1101/2024.01.29.577707Read

SKSR1 identified as key virulence factor in Cryptosporidium by genetic crossingSemantic proximity Read

Genetic crosses reveal genomic loci responsible for virulence in <i>Cryptosporidium parvum</i> infectionSemantic proximity Read

A loss-of-function mutation in <i>Itgal</i> contributes to the high susceptibility of Collaborative Cross strain CC042 to <i>Salmonella</i> infectionsSemantic proximity Read

Generating and Maintaining Transgenic <i>Cryptosporidium parvum</i> ParasitesSemantic proximity Read

Genetic basis of R-phase H:z <sub>27</sub> antigen expression and phylogenetic relationships of <i>Salmonella enterica</i> serovar SenftenbergSemantic proximity Read

Identification of new loci involved in the host susceptibility to Salmonella Typhimurium in collaborative cross mice.Semantic proximity Read

Genetic background influences survival of infections with <i>Salmonella enterica</i> serovar Typhimurium in the Collaborative CrossSemantic proximity Read

Fine mapping of the chicken salmonellosis resistance locus (SAL1).Semantic proximity Read

Whole genome sequence analysis of 91 <i>Salmonella</i> Enteritidis isolates from mice caught on poultry farms in the mid 1990sSemantic proximity Read

<i>Cryptosporidium</i> Oocyst Wall Proteins are true oocyst wall proteins, with COWP8 functioning to hold the inner and outer layers of the oocyst wall togetherSemantic proximity Read

Genetic modification of the diarrhoeal pathogen Cryptosporidium parvumSemantic proximity Read

Contribution of Salmonella typhimurium virulence factors to diarrheal disease in calves.Semantic proximity Read