Article

Complete loss of<i>SLC30A8</i>in humans improves glucose metabolism and beta cell function

2024-04-07

Abstract excerpt

<h4>ABSTRACT</h4> Genetic association studies have demonstrated that partial loss of SLC30A8 function protects against type 2 diabetes (T2D) in humans, but the impact of complete loss of SLC30A8 function remains unknown. From whole-exome and genome sequencing of 100,814 participants in the Pakistan Genome Resource, we identified fifteen SLC30A8 knockouts, including homozygotes for a variant enriched in South Asian...

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Literature Corpus work: 473cee04-f46f-5e17-a732-8a350d5a8876
DOI: 10.1101/2024.04.05.24305397

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