Article

Druggable redox pathways against M. abscessus in cystic fibrosis patient-derived airway organoids

2022-01-03

Abstract excerpt

Mycobacterium abscessus (Mabs) drives life-shortening mortality in cystic fibrosis (CF) patients, primarily because of its resistance to chemotherapeutic agents. To date, our knowledge on the host and bacterial determinants driving Mabs pathology in CF patient lung remains rudimentary. Here, we used human airway organoids (AOs) microinjected with smooth (S) or rough (R-)Mabs to evaluate bacteria fitness, host resp...

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Literature Corpus work: 468e019f-1752-5e27-b9fd-93eccc7c28d2
DOI: 10.1101/2022.01.03.474765

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