Changes in mRNA abundance drive shuttling of RNA binding proteins, linking cytoplasmic RNA degradation to transcription

Abstract excerpt

Alterations in global mRNA decay broadly impact multiple stages of gene expression, although signals that connect these processes are incompletely defined. Here, we used tandem mass tag labeling coupled with mass spectrometry to reveal that changing the mRNA decay landscape, as frequently occurs during viral infection, results in subcellular redistribution of RNA binding proteins (RBPs) in human cells. Acceleratin...

Topics

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• Endoplasmic Reticulum Stress and Disease
• RNA and protein synthesis mechanisms
• RNA regulation and disease
• RNA Research and Splicing
• Telomeres, Telomerase, and Senescence
• Viral Infections and Immunology Research

Identifiers and source

Literature Corpus work

467dcc8e-aa48-5e47-a291-ba6c66c00694

DOI

10.1101/295972