Back to search

Article

Ketogenic diet therapy for pediatric epilepsy is associated with alterations in the human gut microbiome that confer seizure resistance in mice

2023-03-21

Abstract excerpt

<h4>SUMMARY</h4> The gut microbiome modulates seizure susceptibility and the anti-seizure effects of the ketogenic diet (KD) in animal models, but whether these relationships translate to KD therapies for human drug-resistant epilepsy is unclear. Herein, we find that the clinical KD shifts the function of the gut microbiome in children with refractory epilepsy. Colonizing mice with KD-associated human gut microbe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
464f3aa6-2e0f-5a18-854a-e4897e2fd695
DOI
10.1101/2023.03.17.533243
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Ketogenic diet therapy for pediatric epilepsy is associated with alterations in the human gut microbiome that confer seizure resistance in miceDOI 10.1101/2023.03.17.533243
Dietary fiber content in clinical ketogenic diets modifies the gut microbiome and seizure resistance in miceSemantic proximity
Dietary fiber content in clinical ketogenic diets modifies the gut microbiome and seizure resistance in miceSemantic proximity
Exploring the Frontier: the Human Microbiome's Role in Rare Childhood Neurological Diseases and EpilepsySemantic proximity
Effects of ketogenic diet on the classification and functional composition of intestinal flora in children with mitochondrial epilepsySemantic proximity
The ketogenic diet influences taxonomic and functional composition of the gut microbiota in children with severe epilepsySemantic proximity
Ketogenic diet poses a significant effect on imbalanced gut microbiota in infants with refractory epilepsySemantic proximity
The impact of Scn1a deficiency and ketogenic diet on the intestinal microbiome: A study in a genetic Dravet mouse modelSemantic proximity
The gut microbiome in drug‐resistant epilepsySemantic proximity
Cross talk between drug‐resistant epilepsy and the gut microbiomeSemantic proximity
The fecal metabolome and microbiome are altered in dogs with idiopathic epilepsy compared to healthy dogsSemantic proximity
Gut Pharmacomicrobiomics: the tip of an iceberg of complex interactions between drugs and gut-associated microbesSemantic proximity
A comparison of the gut microbiota among adult patients with drug-responsive and drug-resistant epilepsy: An exploratory studySemantic proximity
Select a neighboring publication to make it the new centre.