Article

Patient-informed biomechanical modelling reveals mechanical mechanism of brain damage in idiopathic normal pressure hydrocephalus

2026-04-30

Abstract excerpt

Idiopathic normal pressure hydrocephalus (iNPH) is a globally growing neurological disorder in older adults, radiologically characterised by enlargement of ventricles. However, it remains unknown whether ventricular enlargement can produce biomechanical loading large enough to drive brain morphological changes and tissue damage. Here, we develop an anatomically detailed biomechanical model of ageing human brain an...

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Literature Corpus work: 45bedc61-102e-57ae-9334-7a882f24273b
DOI: 10.64898/2026.04.27.721128

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