Article

Targeting MALAT1 Augments Sensitivity to PARP Inhibition by Impairing Homologous Recombination in Prostate Cancer

2023-02-03

Abstract excerpt

Poly (ADP-ribose) polymerase inhibitors (PARPi) have emerged as a promising targeted therapeutic intervention for the treatment of metastatic castrate-resistant prostate cancer (mCRPC). However, the clinical utility of PARPi has been limited to a subset of patients who harbour aberrations in the genes associated with the homologous recombination (HR) pathway. Here, we report that targeting metastasis-associated lu...

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Literature Corpus work: 43d36e31-aac2-5e99-9d18-5fd3b534cf6e
DOI: 10.21203/rs.3.rs-2534086/v1

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