Article

Identification of a Novel apoB Variant in a Family Exhibiting Hypocholesterolemia: Mechanistic Insights

2025-11-20

Abstract excerpt

Familial hypobetalipoproteinemia (FHBL) is a rare autosomal codominant disorder. FHBL is often caused by a defect in apoB production that is required for lipoprotein formation. Here we identified three family members that exhibited very low circulating cholesterol levels. Analyses of their plasma lipid profiles revealed that the affected individuals have low levels of cholesterol and LDL-cholesterol (LDLc) lipopro...

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Literature Corpus work: 43540f49-34aa-5509-b84c-1fefd970ff8c
DOI: 10.20944/preprints202511.1618.v1

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