Article

Enhancing bacteriophage therapeutics through <i>in situ</i> production and release of heterologous antimicrobial effectors

2022-03-09

Abstract excerpt

Bacteriophages operate via pathogen-specific mechanisms of action distinct from conventional, broad-spectrum antibiotics and are emerging as promising alternatives. However, phage-mediated killing is often limited by bacterial resistance development (1,2). Here, we engineer phages for target-specific effector gene delivery and host-dependent production of colicin-like bacteriocins and cell wall hydrolases. Using u...

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Literature Corpus work: 41dc4042-5e42-5982-934c-4fc0fa511a0f
DOI: 10.1101/2022.03.09.483629

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