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Epidemiology of malignant hyperthermia in the UK 1988-2025: implications for prevalence, mode of inheritance, relative risk associated with <i>RYR1</i> genotypes and <i>in vitro</i> contracture test phenotype

2026-03-05

Abstract excerpt

<h4>Background</h4> There is disparity between the incidence of malignant hyperthermia (MH) reactions and the prevalence of variants in the RYR1 gene associated with susceptibility to MH (where susceptibility is determined by in vitro contracture tests). Our aims were to use clinical and genetic data from the UK to explain this disparity and to examine if these data are consistent with the clinical risk of MH b...

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Literature Corpus work
3fa2d2a8-8bd9-509d-9163-fd0e9f9a4dbd
DOI
10.64898/2026.03.05.26347692
Open publication

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Epidemiology of malignant hyperthermia in the UK 1988-2025: implications for prevalence, mode of inheritance, relative risk associated with <i>RYR1</i> genotypes and <i>in vitro</i> contracture test phenotypeDOI 10.64898/2026.03.05.26347692
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