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Article

Genome-wide diversity of chromosomal inversions and their disease relationships

2025-09-26

Abstract excerpt

Chromosomal inversions shape evolution and are implicated in human disease, yet their effects on genomic variation and health outcomes remain poorly understood. We analyze genome-wide human inversion polymorphisms, contrasting single-event and recurrent loci. Inversion recurrence is validated using structured-coalescent simulations. We show that single-event inversions evolve in near-complete isolation: inverted h...

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Literature Corpus work
3e285ea4-1d8c-5d4b-b259-6e5b8bda1c08
DOI
10.1101/2025.09.25.678440
Open publication

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Genome-wide diversity of chromosomal inversions and their disease relationshipsDOI 10.1101/2025.09.25.678440
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