Article

Detecting adaptive changes in gene copy number distribution accompanying the human out-of-Africa expansion

2023-08-14

Abstract excerpt

Genes with multiple copies are likely to be maintained by stabilizing selection that puts a bound to unlimited expansion of copy number. We designed a model where copy number variation is generated by unequal recombination, which fits well to a number of genes, surveyed in three human populations. Based on this theoretical model and on computer simulations, we were interested in answering the question whether gene...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3ddd58a6-32e0-52a7-96d8-3f9ee1520e83
DOI: 10.1101/2023.08.14.553171

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Detecting adaptive changes in gene copy number distribution accompanying the human out-of-Africa expansionDOI 10.1101/2023.08.14.553171Read

Recombination, selection, and the evolution of tandem gene arrays.Semantic proximity Read

Recombination, selection and the evolution of tandem gene arraysSemantic proximity Read

Rethinking human <i>AMY1</i> copy number evolution in light of demographic historySemantic proximity Read

A highly variable segment of human subterminal 16p reveals a history of population growth for modern humans outstide Africa.Semantic proximity Read

Global diversity, population stratification, and selection of human copy-number variation.Semantic proximity Read

Statistical evaluation of alternative models of human evolution.Semantic proximity Read

Complex genetic patterns in human arise from a simple range-expansion model over continental landmassesSemantic proximity Read

The impact of recent population history on the deleterious mutation load in humans and close evolutionary relativesSemantic proximity Read

The impact of recent population history on the deleterious mutation load in humans and close evolutionary relatives.Semantic proximity Read

Phylogenetics of worldwide human populations as determined by polymorphic Alu insertions.Semantic proximity Read

Detection of convergent genome-wide signals of adaptation to tropical forests in humans.Semantic proximity Read

Interrogating multiple aspects of variation in a full resequencing data set to infer human population size changes.Semantic proximity Read