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The Melanin Loop: A Self-Amplifying Electrophilic Cycle in Hyperpigmentation and Photoaging

2026-06-19

Abstract excerpt

Melanin biosynthesis proceeds through dopaquinone, a reactive ortho-quinone that partitions between eumelanin and pheomelanin depending on local thiol availability. When intracellular cysteine and glutathione are sufficient, dopaquinone is intercepted to form cysteinyldopa and ultimately pheomelanin. When thiols are depleted, dopaquinone undergoes intramolecular cyclization toward eumelanin through dopachrome, DHI...

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Literature Corpus work
3c8ccc18-e465-5304-9a64-4709ed223d32
DOI
10.20944/preprints202606.1463.v1
Open publication

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