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Ayurveda based phenotype annotation integrated with Expectation Maximization algorithm reveal six biological clusters of rare diseases: potential in resolving ciliopathies

2024-09-19

Abstract excerpt

<h4>ABSTRACT</h4> Managing rare genetic diseases with an organ-centric approach poses challenges in linking genotypes to phenotypes. Ayurveda, however, takes a multisystem perspective, assessing diseases through kinetic ( Vata:V ), metabolic ( Pitta:P ), and structural ( Kapha:K ) dimensions, each with distinct phenotypic and molecular correlates. This study explores rare diseases from a systems perspective by...

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Literature Corpus work: 3c85172c-dc27-5e45-94f9-787002bfe789
DOI: 10.1101/2024.09.13.612844

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